23 February, 2026 · 2 minutes of reading
PDRN and PN (polynucleotides) represent the new generation of biotechnological actives in regenerative cosmetics. Their strategic combination enables deep cellular regeneration while reinforcing the skin barrier, aligning with the growing demand for science-driven, high-performance solutions.
The cosmetics industry is evolving toward a more scientific, more technical, and more demanding model. Today, the market is no longer looking only for hydration — it seeks cellular regeneration, biological activation, and measurable results.
In this context, PDRN (polydeoxyribonucleotide) and PN (polynucleotides) are emerging as key actives in the development of advanced cosmetics and high-performance dermocosmetics.
PDRN and PN: activation and protection in one single approach
PDRN, with a lower molecular weight, enhances skin penetration and works by stimulating:
- Collagen synthesis
- Cellular regeneration
- Tissue repair
PN, with a higher molecular weight, reinforce the skin barrier and improve:
- Moisture retention
- Barrier function
- Protection against external aggressors
The strategic combination of both enables a 360° approach: deep repair + structural protection, aligned with the current demand of the premium and medical-aesthetic market.
A global trend driven by biotechnology
The growth of PDRN in Asia — particularly in South Korea — confirms the consolidation of regenerative cosmetics as the new industry standard. Its expansion into categories such as suncare, eye care, and haircare demonstrates its versatility and positioning potential.
Moreover, the evolution toward plant-derived PDRN and advanced encapsulation systems strengthens its relevance in a market that demands efficacy, sustainability, and technological differentiation.
From trend to strategic opportunity
Incorporating PDRN and PN is not simply about adding an ingredient. It requires defining a formulation strategy, selecting the appropriate technology, and ensuring stability, compatibility, and regulatory compliance. This is where third-party manufacturing makes the difference.
At Neftis Laboratorios, we develop solutions based on next-generation biotechnological actives, transforming innovation into scalable, safe products ready for the international market.
Because in modern cosmetics, following a trend is not enough. You need to know how to develop it.